Top 50 Inc.500|5000 Companies by Metro Area -- Nashville-Davidson--Murfreesboro-Franklin, TN
| ▲ | Company | City | State | Rank | Industry | Revenue | Growth |
| 1 | Simplex Healthcare | Brentwood | TN | 335 | Health | $56.7 million | 727.4% |
| 2 | Emma | Nashville | TN | 510 | Business Products & Services | $8.3 million | 520.5% |
| 3 | Buffalo Lumber | Woodbury | TN | 585 | Construction | $2.1 million | 463.4% |
| 4 | Community Ties of America | Brentwood | TN | 673 | Health | $4.5 million | 412.5% |
| 5 | SRS | Gallatin | TN | 731 | Construction | $20.3 million | 392.0% |
| 6 | Universal Safety Response | Franklin | TN | 852 | Security | $22.9 million | 351.3% |
| 7 | LeGacy Resource | Brentwood | TN | 891 | Government Services | $14.9 million | 339.8% |
| 8 | The ADAM Group | Franklin | TN | 917 | Advertising & Marketing | $8.1 million | 329.6% |
| 9 | Vaco | Brentwood | TN | 927 | Human Resources | $116.0 million | 328.1% |
| 10 | Sitters Etc. | Brentwood | TN | 977 | Health | $4.2 million | 313.2% |
| 11 | Guy Brown Products | Brentwood | TN | 1009 | Business Products & Services | $205.8 million | 303.9% |
| 12 | Profitpoint | Franklin | TN | 1013 | Financial Services | $8.9 million | 302.9% |
| 13 | Choice Food Group | Nashville | TN | 1151 | Food & Beverage | $101.3 million | 275.8% |
| 14 | Smuka Trading | Franklin | TN | 1340 | Manufacturing | $2.3 million | 238.3% |
| 15 | Cumberland Pharmaceuticals | Nashville | TN | 1404 | Health | $35.1 million | 228.1% |
| 16 | Centerre Healthcare | Brentwood | TN | 1550 | Health | $27.9 million | 206.4% |
| 17 | Malcap Mortgage | Brentwood | TN | 1661 | Financial Services | $2.4 million | 193.5% |
| 18 | LetterLogic | Nashville | TN | 1833 | Business Products & Services | $11.9 million | 173.9% |
| 19 | PureSafety | Nashville | TN | 1874 | Software | $18.9 million | 169.7% |
| 20 | One Source | Franklin | TN | 1909 | Business Products & Services | $9.0 million | 166.6% |
| 21 | The Human Capital Group | Brentwood | TN | 2079 | Human Resources | $2.3 million | 152.9% |
| 22 | CompNation | Franklin | TN | 2218 | Retail | $8.3 million | 141.7% |
| 23 | Franklin American Mortgage | Franklin | TN | 2231 | Financial Services | $154.8 million | 140.2% |
| 24 | Victor Results Advertising | Brentwood | TN | 2254 | Advertising & Marketing | $8.3 million | 138.9% |
| 25 | Paramore-Redd Online Marketing | Nashville | TN | 2285 | Advertising & Marketing | $3.8 million | 135.8% |
| 26 | Dixie Medical | Franklin | TN | 2315 | Health | $10.2 million | 132.7% |
| 27 | Passport Health Communications | Franklin | TN | 2394 | Health | $56.4 million | 126.8% |
| 28 | MyOfficeProducts | Brentwood | TN | 2405 | Business Products & Services | $92.2 million | 125.9% |
| 29 | Powder X Coating Systems | Smyrna | TN | 2426 | Manufacturing | $3.8 million | 124.4% |
| 30 | Document Solutions | Nashville | TN | 2515 | Business Products & Services | $5.7 million | 119.2% |
| 31 | Cybera | Franklin | TN | 2553 | Telecommunications | $19.3 million | 116.8% |
| 32 | IMI Health | Brentwood | TN | 2595 | Health | $3.1 million | 114.4% |
| 33 | Redpepper | Nashville | TN | 2661 | Advertising & Marketing | $3.7 million | 110.9% |
| 34 | ASE Technology | Franklin | TN | 2810 | Business Products & Services | $3.4 million | 101.6% |
| 35 | Uniguest | Nashville | TN | 9999 | Business Products & Services | $4.7 million | 782.4% |
| 36 | Cumberland Consulting Group | Brentwood | TN | 3060 | IT Services | $8.0 million | 88.8% |
| 37 | Magazines.com | Franklin | TN | 3072 | Retail | $24.8 million | 88.1% |
| 38 | Posh Boutique | Nashville | TN | 3147 | Retail | $3.6 million | 84.6% |
| 39 | USr Healthcare | Brentwood | TN | 3193 | Health | $6.4 million | 82.9% |
| 41 | Sole Supports | Lyles | TN | 3218 | Health | $8.0 million | 81.7% |
| 42 | Optimum Technology Solutions | Nashville | TN | 3240 | IT Services | $3.5 million | 80.3% |
| 43 | Educational Services of America | Nashville | TN | 3277 | Education | $88.1 million | 78.7% |
| 44 | NovaCopy | Nashville | TN | 3284 | Business Products & Services | $26.7 million | 78.2% |
| 45 | Mankin Media Systems | Franklin | TN | 3418 | Media | $2.5 million | 72.4% |
| 46 | Hiller Plumbing, Heating & Cooling | Nashville | TN | 3497 | Construction | $24.1 million | 69.5% |
| 47 | August Enterprises | Nashville | TN | 3595 | Manufacturing | $3.0 million | 66.0% |
| 48 | IASIS Healthcare | Franklin | TN | 4288 | Health | $2.1 billion | 39.2% |
| 49 | Exhibitor Source | La Vergne | TN | 4329 | Advertising & Marketing | $5.1 million | 38.0% |
| 50 | Video Gaming Technologies | Brentwood | TN | 4415 | Consumer Products & Services | $199.3 million | 34.6% |
