The Economy Entrepreneurs want a confident leader who will allay fears fueled by the subprime mortgage mess and $90-a-barrel oil.

Health Care High costs continue to cut into profit margins, and the issue is becoming more pressing, given the aging work force.

National Security Some talk about counterterrorism; others worry about American prestige. All agree security trumps all other issues.

Globalization Though most of them operate locally, they are feeling the pressure--and seeing the opportunities--of global markets.