If you're still pondering whether to head to Silicon Valley for your next startup, you're not thinking big enough or far enough. Over the coming decade, the 600 largest and best-connected cities on the planet will contain a fifth of the world's population, capture almost two-thirds of its economic growth, and encompass more than half of global GDP, according to the McKinsey Global Institute. And, as great as the Bay Area and Boulder and Austin are for launching a startup, you'd be only scratching the surface here when it comes to corralling talent, tapping the world's next big market (hint: they speak Arabic), or being present for the next tech breakthrough.

America's entrepreneurial spirit is too big to be contained by borders. Here, we present five global alternatives to traditional hotbeds of startup creation and growth. Each city offers unique advantages to American entrepreneurs, and each is a regional--or even global--hub in its own right. Some are great places to launch a business or expand into new markets. Others offer access to expertise or technologies that may not yet be available in the U.S. Many are home to some of the world's best workers, as well as to partners who will help you scale.

For example, Istanbul and Dubai are gateways to the modern Middle East, a market that is growing faster than (and is younger and bigger than) that of the United States. Santiago, Chile, has made a name for itself as one of the most foreign-entrepreneur-friendly cities on the planet, and as a test bed for launching into Latin America. Tallinn, Estonia, is one of the world's most internet-connected cities, with a deep pool of technical talent thanks to all the Skype alumni running around. Shenzhen, China, aspires to be the Silicon Valley for hardware makers, a place where accelerators are eager to help you build, test, refine, and make a million of something all in the same day. If these cities aren't already on your radar as lands of opportunity for your company, let this serve as notice that they should be.