Meet the 5 Most Powerful Women in Gaming

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thatgamecompany | Kellee Santiago

Santiago's Flower and flOw video games were commercial and critical successes that turned traditional gaming on its head. "They created this user experience that was about things other than competition," says Swain, the USC professor.

Santiago sets herself apart with games that allow a player to control the wind or an aquatic microorganism. Flower also ranked in Sony's top 10 Playstation games for two years in a row, while the PS3 follow-up Journey swept several video game awards last year, plus a Grammy nomination for Best Original Soundtrack.