As speculation swirls around Mark Zuckerberg running for office someday, he continues to surround himself with powerful political figures.

The Facebook founder and his wife Priscilla Chan announced on Tuesday that David Plouffe, Uber's chief advisor and former Obama campaign manager, will be joining the their philanthropic initiative to lead policy and advocacy efforts. He will still remain on Uber's board of directors.

Launched in 2015 around the birth of the couple's daughter Max, the Chan Zuckerberg Initiative seeks to make social change through engineering, science, and education. In September, CZI committed $3 billion to help fund cures for all the diseases facing humanity by 2100 as part of Zuckerberg's promise to donate 99 percent of his Facebook shares (a $45 billion-value in September 2015 when he announced the pledge).

Political advocacy is a critical part in building a social movement around change, Zuckerberg said in the statement about Plouffe's new role. "When we launched our science initiative last year, I spoke about how we need to change that our government spends 50x more treating people who are sick than finding cures so people don't get sick in the first place," he wrote.

Adding more political firepower, Zuckerberg also announced that Ken Mehlman will be leading the CZI board. Mehlman ran the Republican National Committee, and formerly served as George W. Bush's campaign manager.