To get the maximum benefit from your first cup of coffee, don't drink it when you first get out of bed or during your commute. Instead, wait until you're already at work. The reason is simple.
When you wake up, your body releases cortisol, a hormone that works similarly to caffeine. Adding caffeine to cortisol can create stress (you overdose on energy). At about two hours, though, your cortisol level drops, making it the perfect time for a jolt of caffeine.
The implication here is that you should start your workday with a coffee break, rather than do what most people do, which is have their first cup when they wake up and their second cup around 10:30 a.m.--a traditional coffee-break time.