Business owners turned their attention over the past few days squarely toward the Iowa caucuses, the first national contest in the 2016 presidential election. Once the results were in, many big-name entrepreneurs--including the always-outspoken Mark Cuban--did not hold back on voicing their opinions.

On the Democratic side, former Secretary of State Hillary Clinton and Vermont senator Bernie Sanders were neck and neck, with 49.9 percent and 49.6 percent of the vote, respectively. And despite polling ahead of all the other Republican candidates for months, real estate mogul and billionaire Donald Trump was dealt a surprising upset: Texas senator Ted Cruz  walked away with 27.6 percent of the vote, to Trump's 24.3 percent.

There was more than a little schadenfreude among famous entrepreneurs on social media about the sudden turn of events for Trump. Many openly delighted in seeing a second-place finish for a campaign that has often been full of offensive bluster and seemingly never had considered the prospect of losing.

A handful of celebrity business owners had choice words for the other candidates as well. Here's a look at some reactions:

Y Combinator president and serial entrepreneur Sam Altman used some of Trump's more vulgar language about presidential hopeful Hillary Clinton to describe the billionaire's loss:

Venture capitalist and Netscape founder Marc Andreessen used another of Trump's own go-to insults:

Arianna Huffington, co-founder of the Huffington Post, posed a serious question about the meaning of losing:

America Online co-founder and former chief executive Steve Case made a pitch for stronger, less-divisive leadership, citing the example of Franklin D. Roosevelt:

And entrepreneur and Shark Tank personality Mark Cuban took aim at winner Ted Cruz, right before the vote: