Nonin--short for noninvasive--invented fingertip pulse oximeters nearly 25 years ago. Those devices, which measure how well a person is absorbing oxygen, have been vital in the fight against Covid-19. Demand skyrocketed this year, and Nonin worked through a supply chain shortage to ramp up production, donating many of its devices to underserved communities in St. Paul and Minneapolis. The company also received FDA clearance for another device, the first-ever handheld wireless device capable of reading multiple vital signs.

From the onset of the pandemic, Capsule has partnered with local communities and governments to ensure that the elderly, immunocompromised, and other vulnerable populations are safe and healthy, and that they have uninterrupted access to critical medications. It also collaborated with Oscar Health and men’s wellness startup Hims to beef up its health care experience as it expanded into five new states. As health care systems digitized overnight, the company's seamless digital platform enabled more consumers to fill prescriptions that may have otherwise gone unused.

This company's telehealth app was already offering text-based primary health care when demand surged because of the Covid-19 pandemic. 98point6 spent this year expanding rapidly, tripling the number of physicians participating in its network, and adding commercial partnerships with giants like Boeing, Chipotle, Circle K, and KinderCare to provide text-based primary care to millions of employees and dependents during a time of heightened need. Chief medical officer Brad Younggren is a doctor at EvergreenHealth in Kirkland, Washington, the first U.S. hospital to identify a Covid-19 outbreak.

 As a widely-cited source for small-business data, Homebase helped Americans -- including policymakers, economists, and journalists -- grasp the impact of Covid-19 on business and the economy. It also built a financial resources site for both businesses and workers, partnered with lenders to facilitate Paycheck Protection Program loan applications, and offered a range of small-business resources, including support from certified HR professionals, symptom-screening tools, and a re-opening toolkit.