Binge drinking is nothing to joke about. Excessive alcohol use is the leading cause of preventable death, according to the Centers for Disease Control and Prevention. The hangover is also costly: Excessive drinking costs the U.S. more than $223 billion annually, the CDC found in a 2006 report, with lost workplace productivity claiming 72 percent of that cost.

That's not a good forecast for your business come January 1, considering New Year's Eve is the most notorious night of the year for overindulging in libations. And even if you're planning to close up shop that day, there's a good chance that someone's hard-partying ways will impact your company sometime this year.

Although most doctors believe there is no "cure" for a hangover other than time, there is a slew of treatments centered around getting you back on your feet after a long night out. It may be worth your employees' time (and your own) to try something out, if only for the potential placebo effect. Below, read about three of the more interesting entrepreneurial ventures trying to get rid of your hangover.

1. Patch up your splitting headache with ByTox

When you drink to excess, you are flooding your body with toxins. Your liver starts to work hard to flush them from your body, but the diuretic effect also takes good vitamins and nutrients along with it. The morning after, your body is depleted of essential materials. To prevent that from happening, Brooklyn, New York-based ByTox offers its Hangover Patch. You just slap it on your arm, wait 45 minutes, and then drink to your heart and liver's content for eight hours. 

The patch, created by plastic surgeon Leonard Grossman and cellphone store owner Alex Fleyshmakher, is packed with a 12 organic vitamins, nutrients, and antioxidants for reducing the severity of hangovers. Fleyshmakher tells The New York Times he got the idea for the company following a rough night of drinking. Before going to work the next day, he went to a Grossman's office for IV fluids and recovered. Soon afterward the two teamed up to build the company, infusing the patch with a similar mixture of vitamins and minerals

2. Just what the doctor ordered

HungoverMD's co-founders, Steven Murphy and Josh Shajan, call their service the "Uber for IVs." For $179, you can go to one of their two locations in New York City and Greenwich, Connecticut to receive a screening from a licensed medical professional and get hooked up to a 1-liter IV bag containing a cocktail of saline and electrolytes. You can also get medication to help with your headache, upset stomach, and nausea. For an extra $20, the doctors will make a house or office call, just like the old days.

3. Two ounces of prevention

When you drink, your liver turns alcohol into a toxin called acetaldehyde, which makes you feel terrible in the morning. Never Hungover claims its formula, containing vitamins, antioxidants, amino acids, and other nutrients, turns the acetaldehydes into acetic acid and flushes it out of your body. The 2-ounce bottle is meant to be taken an hour before you drink. 

CEO Parrish Whitake founded the company after his sister was diagnosed with the autoimmune disease lupus. His father donated one his kidneys to her, and while they were both recuperating, a holistic doctor prescribed them a formula of nutrients and antioxidants. Impressed by his family members' recovery, Whitake started experimenting with the formula and found that it worked great to help reduce the effects of a hangover. Maloof Ventures acquired Never Hungover in 2013.