Move over, Black Friday: In between helpings of stuffing this Thanksgiving Day, a record number of online shoppers emptied their wallets to buy gifts.

According to a new report by ChannelAdvisor, a cloud-based e-commerce sales management platform, online sales during the Thursday holiday were up 43.4 percent from last year. Mobile devices accounted for 64 percent of online shopping on Turkey Day, up from 49 percent in 2014. 

Several prominent e-commerce sites experienced significant Thanksgiving sales increases as well.  Amazon's sales grew 28.9 percent year over year, while eBay's sales increased 7 percent. 

Growth was especially strong among large "third-party marketplace" sellers such as Best Buy and Sears, according to Channel Advisor, which recorded the gross merchandise value of thousands of retailers to compile the results. "This indicates that these 'Brick and Clicks' retailers were really able to tie their store and online promotions together with great success," Channel Advisor executive chairman Scot Wingo said in a press release.

The report goes to show that e-commerce businesses must be prepared to cater to the growing number of shoppers hungry for deals prior to Black Friday. What remains unclear is whether strong Thanksgiving Day sales indicate that customers will continue to buy through the December holidays.